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AAT Bioquest
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Buccutite™ Crosslinking Technology
Buccutite™ crosslinking technology provides a simplistic and efficient approach to conjugate proteins with another macromolecule such as an antibody or an enzyme. Buccutite™ crosslinking technology utilizes two exclusive linkers, Buccutite™ FOL, SE and Buccutite™ MTA, SE. The unique properties of these Buccutite™ crosslinkers allow them to function separately as two halves of a single homobifunctional crosslinker. Each Buccutite™ crosslinker is engineered to have an amine-reactive group on one end which specifically targets primary amines on the desired protein. The other end contains our proprietary Buccutite™-reactive group, which has a high degree of affinity for only binding its respective Buccutite™ MTA/FOL crosslinker counterpart. When each is present, the two Buccutite™-protein conjugates covalently link together at their Buccutite™-reactive site, "like buckling a seat belt," to successfully create a protein-protein conjugate.
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Info AAT Bioquest
AAT Bioquest, Inc. develops, manufactures and markets bioanalytical research reagents and kits to scientists engaged in life sciences research, diagnostic R&D and drug discovery. They specialize in the area of photometric detections including absorption (color), fluorescence and luminescence technologies.
AAT Bioquest constantly introduces new products, and offers a rapidly expanding list of products that are grouped into several product lines.
1) Reactive fluorescent and luminescent probes, biotins and tag enzymes are used for labeling small drug molecules and biopolymers, e.g, proteins, nucleic acids and carbohydrates;
2) Fluorescent and luminescent probes for detecting proteins, nucleic acids and live cells;
3) Novel fluorescent and luminescent probes for detecting various enzymes, in particular, hydrolytic and redox enzymes;
4) Reagents for signal transduction research;
5) Physiological and neurological probes, e.g., calcium indicators and membrane potential probes.
For more information:
http://www.aatbio.com
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