Vitro SA

Vitro SA

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CE-IVD Antibodies for IHC Diagnostics
PAX-8 - Clone MD-50 (also known as MRQ-50)

PAX 8 is an important factor for the embryological development of the thyroid, the Müllerian system, kidneys, and the upper urinary tract. PAX 8 continues to be expressed in adult thyroid tissue and is detected in normal renal epithelium, in all segments of the renal tubules from the proximal tubule to the renal papilla and parietal epithelium of Bowman's capsule. 
An intense PAX8 nuclear signal is present in: thyroid tumors, clear cell renal cell carcinomas (CRCC), sarcomatoid CRCCs, renal oncocytomas, renal chromophobe carcinomas, and renal medullary carcinomas; also serous ovarian carcinomas of high degree, non-serous ovarian epithelial neoplasms, cervical epithelial lesions, endometrial adenocarcinomas, and a subset of thymic carcinomas might also be positive.

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Napsin A - Clone BS10

Napsin is a pepsin-like aspartic proteinase, in the A1 group of the AA class of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. 
Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs. 

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p16-INK4 - Clone MX007

As one of the cyclindependent kinase inhibitors that inhibit cylcindependent kinases 4 and 6, p16 INK4A is encoded by tumor suppressor gene CDKN2A. The tumor suppressor p16 INK4A plays an important role in cell cycle regulation.
Mutations in the p16 gene associated with loss or over expression of the protein are associated with increased risk of a wide range of cancers and cancer precursor lesions. The immunohistochemical identification of p16 is particularly relevant in uterine cervical lesions. 
Although the frequency of p16INK4a abnormalities is higher in tumor-derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

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Info Vitro SA

Antibodies optimized for the pathologic diagnosis

Vitro is a manufacturer of equipment, software and reagents for in-vitro diagnostics (IVD) through the application of techniques based on non-invasive tests, such as immunohistochemistry and molecular biology techniques. Their broad portfolio includes primary antibodies, ultra-sensitive micro polymer-based universal detection systems and auxiliary reagents. The top quality primary antibodies are optimized for pathological diagnosis on tissue sections fixed in buffered formalin and paraffin embedded.
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