Borrelia VlsE1/pepC10 IgG/IgM ELISA kit

Lyme disease is the most common tick-borne disease in the Northern Hemisphere, and is caused by infection with Borrelia, a group of spirochetal bacteria commonly transferred from tick bites. Serological evidence of exposure is an important aid in the diagnosis of Lyme disease, and the development of recombinant and synthetic antigens has brought about second generation assays with improved clinical specificity and sensitivity¹.
 

Two antigens are better than one. • Why VlsE1? The VlsE1 protein has several      immunodominant epitopes, including C6,    which can improve clinical diagnostic    sensitivity • Why pepC10? pepC10 is a peptide derived    from Outer Surface Protein C (OspC), which is    the immunodominant antigen of the IgM    response in Lyme disease. Detection of IgM    antibodies to pepC10 can be especially helpful    in the diagnosis of acute Lyme disease2. • The VlsE1/pepC10 is ideal for serodiagnosis of    major infectious European Lyme disease (B.    afzelii, B. garinii, B burgdorferi ). (See Figure 1)3

Product Features
• Achieves superior clinical sensitivity and specificity by testing two antigens, VlsE1 + pepC10, in the same well.
• Yields excellent assay reproducibility using highly purified and specific antigens.
• Adapts to your workflow with flexibility for manual, semi-automated, or fully-automated operation.

 Ordering Information

Catalog No:	Product Description
3Z9661	Borrelia VlsE1/pepC10 IgG/IgM Test System (96 tests)

More information: ZEUS ELISA™ Borrelia VlsE1/pepC10 IgG/IgM Test System Flyer

1. Wilske, B., et al. 2007. Microbiological and serological diagnosis of Lyme borreliosis. FEMS Immunol Med Microbiol 49:13-21.
2. Bacon, R., et al. 2003. Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent assay Using Recombinant  VIsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing using Whole-Cell Lysate. J Infect Dis. 187:1187-1199.
3. Dibernardo, A., et al. Laboratory evaluation of the performance of the ZEUS PEPC10/VIsE ELISA to detect antibodies to members of the European genospecies of Borrelia burgdorferi sensu late. Public Health Ontario.